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performed a single-blind, randomized, crossover two-arm study to assess the effects of nicotine on the disposition kinetics of intravenously infused deuterium-labelled nicotine and cotinine and oral chlorzoxazone, verifying the hypotheses that nicotine reduces its own CYP2A6-mediated metabolism and induces CYP2E1 activity

"So when we're talking about loss of life expectancy, life expectancy would tend to live in relatively good health." "The time they're losing is time that they could be spending with their loved ones in fairly good health," she said

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